PIV = parainfluenza virus; RSV = respiratory syncytial virus; MPV = metapneumovirus; Group A Strept = group A streptococcus.
Findings from a study by Hills and colleagues suggest that the strong effect of minor infections on the risk of stroke in children is short-lived.
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Rhinoviruses (RVs) chiefly cause upper respiratory tract infections, but may also infect the lower respiratory tract. Although RV infections occur year-round, the incidence is highest in the fall and the spring (see the image below).
Seasonal variations in frequency of selected upper respiratory tract infection pathogens.
Antioxidants may provide insufficient neuroprotection after HI for neonatal males in the short term, while long-term therapy may benefit both sexes.
Hypothermia treatment for hypoxic-ischemic (HI) neonates decreases the incidence of severe neurodevelopmental outcomes at 12–24 months of age to approximately 45–55%, without apparent differences in efficacy between sexes (Eicher ., 2010).
Hypothermia alone had no effect in this severe model.
When NAC was continued for 6 weeks, significant improvement in long-term neuromotor outcomes over hypothermia treatment alone was observed, controlling for sex.
NAC 50 mg/kg/d administered 1 h after initiation of hypothermia significantly decreased i NOS expression and caspase 3 activation in the injured hemisphere versus hypothermia alone.
However, only females treated with hypothermia NAC 50 mg/kg showed improvement in short-term infarct volumes compared with saline treated animals.
On a genome-wide level, VGLL3-regulated genes had a strong association with multiple autoimmune diseases, including lupus, scleroderma and Sjögren's syndrome, and had a prominent transcriptomic overlap with inflammatory processes in cutaneous lupus.